Descemet's Membrane Modulation of Posterior Corneal Fibrosis

Posterior Corneal Steepening in Posterior Polymorphous Corneal Dystrophy.

PURPOSE The aim was to evaluate the anterior and posterior corneal topographic characteristics of three patients with posterior polymorphous corneal dystrophy (PPCD) using a rotating Scheimpflug camera combined with a Placido disc system (Sirius, CSO, Italy). CASE REPORTS Two children with unilateral PPCD and a 53-year-old woman with bilateral PPCD were diagnosed by the presence of vesicles a...

Posterior corneal astigmatism.

In the optical system of the human eye, total refractive power consists mainly of corneal and lenticular components. Approximately two-thirds of the eye's converging power is at the air–cornea (tear film) interface; one-third is in the lens. Total corneal power is determined by corneal anterior and posterior curvature, corneal thickness, and the corneal refractive indices. Traditionally, anteri...

Total Corneal Astigmatism and Posterior Corneal Surface.

Contribution of posterior corneal astigmatism to total corneal astigmatism.

PURPOSE To determine the contribution of posterior corneal astigmatism to total corneal astigmatism and the error in estimating total corneal astigmatism from anterior corneal measurements only using a dual-Scheimpflug analyzer. SETTING Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. DESIGN Case series. METHODS Total corneal astigmatism was calculated using ray trac...

Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy

Purpose To investigate the molecular basis of posterior polymorphous corneal dystrophy (PPCD) by examining the PPCD transcriptome and the effect of decreased ZEB1 expression on corneal endothelial cell (CEnC) gene expression. Methods Next-generation RNA sequencing (RNA-seq) analyses of corneal endothelium from two PPCD-affected individuals (one with PPCD3 and one of unknown genetic cause) com...